| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Ligand | BDBM258532 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 8±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | 43±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hunziker, D; Mattei, P; Mauser, H; Prunotto, M; Ullmer, C Diazaspirocycloalkane and azaspirocycloalkane US Patent US9493486 Publication Date 11/15/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 99007.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13822 |
|---|
| Residue: | 863 |
|---|
| Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
|
|
|
|---|
| BDBM258532 |
|---|
| n/a |
|---|
| Name | BDBM258532 |
|---|
| Synonyms: | US10633384, Example 7 | US9493486, 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19Cl2N7O2 |
|---|
| Mol. Mass. | 484.338 |
|---|
| SMILES | Clc1cc(Cl)cc(c1)-c1nnc(o1)N1CCC2(CN(C2)C(=O)c2ccc3[nH]nnc3c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
