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TargetGST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)
LigandBDBM259295
Substrate/Competitorn/a
Meas. Tech.Kinase High ATP Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 2±n/a nM
Commentsextracted
Citation Eis KPuehler FZorn LScholz ALienau PGnoth MJBömer UGünther JHitchcock M Amino-substituted imidazopyridazines US Patent  US9499547 Publication Date 11/22/2016
More Info.:Get all data from this article,  Assay Method
 
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)
Name:GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Glutathione S-transferase Pi
Synonyms:GST class-pi | GSTP1-1 | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P
Type:Enzyme
Mol. Mass.:23353.53
Organism:Homo sapiens (Human)
Description:P09211
Residue:210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
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Component 2
Name:MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Synonyms:MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MNK1a
Type:Protein
Mol. Mass.:47416.00
Organism:Homo sapiens (Human)
Description:Q9BUB5-2 with T344D
Residue:424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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BDBM259295
n/a
NameBDBM259295
Synonyms:US9499547, 36
TypeSmall organic molecule
Emp. Form.C18H15FN4O2
Mol. Mass.338.3357
SMILESN[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1 |r,wU:1.0,wD:3.5,(-6.7,4.12,;-5.37,3.35,;-3.88,3.75,;-3.48,2.26,;-4.97,1.87,;-2.15,1.49,;-.81,2.26,;-.81,3.8,;.52,4.57,;1.85,3.8,;3.32,4.28,;4.22,3.03,;3.32,1.79,;4.09,.45,;3.18,-.79,;4.09,-2.04,;3.77,-3.54,;2.31,-4.02,;4.92,-4.57,;6.38,-4.1,;6.7,-2.59,;5.55,-1.56,;5.55,-.02,;1.85,2.26,;.52,1.49,)|
Structure
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