Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Ligand | BDBM259517 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
IC50 | 0.303±n/a nM | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24581.05 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 946-1162 | ||
Residue: | 217 | ||
Sequence: |
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BDBM259517 | |||
n/a | |||
Name | BDBM259517 | ||
Synonyms: | US9505749, 28 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H26FN5O3 | ||
Mol. Mass. | 475.5147 | ||
SMILES | Fc1ccc(cc1)-c1nnc(o1)[C@H]1CC[C@@H](CC1)NC(=O)CCCc1nc2ccccc2c(=O)[nH]1 |r,wU:15.20,wD:12.13,(.22,-8.75,;1.31,-7.66,;.91,-6.18,;2,-5.09,;3.48,-5.49,;3.88,-6.97,;2.79,-8.06,;4.57,-4.4,;6.11,-4.4,;6.59,-2.93,;5.34,-2.03,;4.1,-2.93,;5.34,-.49,;6.68,.28,;6.68,1.82,;5.34,2.59,;4.01,1.82,;4.01,.28,;5.33,4.13,;3.99,4.9,;3.99,6.44,;2.66,4.13,;1.33,4.9,;-.01,4.13,;-1.34,4.9,;-2.68,4.13,;-4.01,4.9,;-5.34,4.13,;-6.68,4.9,;-6.68,6.44,;-5.34,7.21,;-4.01,6.44,;-2.68,7.21,;-2.68,8.75,;-1.34,6.44,)| | ||
Structure |