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TargetPoly [ADP-ribose] polymerase tankyrase-2 [946-1162]
LigandBDBM259517
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50 0.303±n/a nM
Citation Bregman, HBuchanan, JLChakka, NDimauro, EFGunaydin, HGuzman-Perez, AHua, ZHuang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016
More Info.:Get all data from this article,  Assay Method
 
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Name:Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]
Synonyms:PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2
Type:Enzyme
Mol. Mass.:24581.05
Organism:Homo sapiens (Human)
Description:aa 946-1162
Residue:217
Sequence:
LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKL
WERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENS
SKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSV
TGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG
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  Blast E-value cutoff:
BDBM259517
n/a
NameBDBM259517
Synonyms:US9505749, 28
TypeSmall organic molecule
Emp. Form.C26H26FN5O3
Mol. Mass.475.5147
SMILESFc1ccc(cc1)-c1nnc(o1)[C@H]1CC[C@@H](CC1)NC(=O)CCCc1nc2ccccc2c(=O)[nH]1 |r,wU:15.20,wD:12.13,(.22,-8.75,;1.31,-7.66,;.91,-6.18,;2,-5.09,;3.48,-5.49,;3.88,-6.97,;2.79,-8.06,;4.57,-4.4,;6.11,-4.4,;6.59,-2.93,;5.34,-2.03,;4.1,-2.93,;5.34,-.49,;6.68,.28,;6.68,1.82,;5.34,2.59,;4.01,1.82,;4.01,.28,;5.33,4.13,;3.99,4.9,;3.99,6.44,;2.66,4.13,;1.33,4.9,;-.01,4.13,;-1.34,4.9,;-2.68,4.13,;-4.01,4.9,;-5.34,4.13,;-6.68,4.9,;-6.68,6.44,;-5.34,7.21,;-4.01,6.44,;-2.68,7.21,;-2.68,8.75,;-1.34,6.44,)|
Structure
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