Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Ligand | BDBM259559 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
IC50 | 0.826±n/a nM | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24581.05 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 946-1162 | ||
Residue: | 217 | ||
Sequence: |
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BDBM259559 | |||
n/a | |||
Name | BDBM259559 | ||
Synonyms: | US9505749, 70 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H26N4O3 | ||
Mol. Mass. | 406.4775 | ||
SMILES | O=C(CCCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)Oc1ccncc1 |r,wU:17.18,wD:20.25,(-0,,;-0,-1.54,;-1.34,-2.31,;-2.67,-1.54,;-4,-2.31,;-5.34,-1.54,;-6.67,-2.31,;-8.01,-1.54,;-9.34,-2.31,;-10.67,-1.54,;-10.67,,;-9.34,.77,;-8.01,,;-6.67,.77,;-6.67,2.31,;-5.34,,;1.33,-2.31,;2.66,-1.54,;2.66,,;4.01,.76,;5.33,,;5.33,-1.54,;4.01,-2.3,;6.66,.77,;8,.01,;8.01,-1.53,;9.34,-2.3,;10.67,-1.53,;10.67,.01,;9.34,.77,)| | ||
Structure |