Ki Summary

Reaction Details

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Target

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Ligand

BDBM259567

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

IC50

0.434±n/a nM

Citation

Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016

More Info.:

Get all data from this article, Assay Method

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Name:

Poly [ADP-ribose] polymerase tankyrase-2 [946-1162]

Synonyms:

Type:

Enzyme

Mol. Mass.:

24581.05

Organism:

Homo sapiens (Human)

Description:

aa 946-1162

Residue:

217

Sequence:

LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKL
WERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENS
SKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSV
TGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG

BDBM259567

n/a

Name

BDBM259567

Synonyms:

US9505749, 78

Type

Small organic molecule

Emp. Form.

C25H26N4O3

Mol. Mass.

430.4989

SMILES

O=C(CCCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N |r,wU:17.18,wD:20.25,(-1.33,.39,;-1.33,-1.15,;-2.67,-1.92,;-4,-1.15,;-5.33,-1.92,;-6.67,-1.15,;-8,-1.92,;-9.34,-1.15,;-10.67,-1.92,;-12,-1.15,;-12,.39,;-10.67,1.16,;-9.34,.39,;-8,1.16,;-8,2.7,;-6.67,.39,;,-1.92,;1.33,-1.15,;1.33,.39,;2.67,1.16,;4,.39,;4,-1.15,;2.67,-1.93,;5.33,1.15,;6.67,.38,;6.67,-1.16,;8,-1.93,;9.34,-1.16,;9.34,.38,;8,1.15,;10.67,-1.93,;12,-2.7,)|

Structure