Reaction Details | |||
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Target | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Ligand | BDBM259601 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
IC50 | 0.431±n/a nM | ||
Citation | Bregman, H; Buchanan, JL; Chakka, N; Dimauro, EF; Gunaydin, H; Guzman-Perez, A; Hua, Z; Huang, X Quinazolinone compounds and derivatives thereof US Patent US9505749 Publication Date 11/29/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | |||
Name: | Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] | ||
Synonyms: | PARP5B | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | Tankyrase-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24581.05 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 946-1162 | ||
Residue: | 217 | ||
Sequence: |
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BDBM259601 | |||
n/a | |||
Name | BDBM259601 | ||
Synonyms: | US9505749, 114 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H23ClN4O3S | ||
Mol. Mass. | 482.982 | ||
SMILES | Clc1cc(O[C@H]2CC[C@@H](CC2)NC(=O)CCSc2nc3ccccc3c(=O)[nH]2)ccc1C#N |r,wU:8.11,wD:5.4,(4,-3.47,;5.33,-2.69,;5.33,-1.15,;6.67,-.38,;6.67,1.15,;5.33,1.93,;5.33,3.47,;4,4.23,;2.67,3.47,;2.67,1.93,;4,1.15,;1.33,4.23,;1.33,5.78,;2.67,6.54,;,6.54,;-1.33,5.78,;-2.67,6.54,;-4,5.78,;-4,4.23,;-5.33,3.47,;-5.33,1.93,;-6.67,1.15,;-8,1.93,;-8,3.47,;-6.67,4.23,;-6.67,5.78,;-8,6.54,;-5.33,6.54,;8,-1.15,;8,-2.69,;6.67,-3.47,;6.67,-5,;6.67,-6.54,)| | ||
Structure |