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TargetRibosomal protein S6 kinase alpha-3 [399-740]
LigandBDBM259805
Substrate/Competitorn/a
Meas. Tech.RSK2 Inhibition Assay
pH8±n/a
Temperature295.15±n/a K
IC50 13±n/a nM
Commentsextracted
Citation Taunton, Jr., JWMaglathlin, RSerafimova, ICohen, MSMiller, RPaavilainen, VMcFarland, JKrishnan, S Kinase inhibitors US Patent US9505766 Publication Date 11/29/2016
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase alpha-3 [399-740]
Name:Ribosomal protein S6 kinase alpha-3 [399-740]
Synonyms:ISPK1 | KS6A3_HUMAN | MAPKAPK1B | RPS6KA3 | RSK2 | Ribosomal S6 kinase 2 (RSK-2)
Type:Enzyme
Mol. Mass.:38435.14
Organism:Homo sapiens (Human)
Description:aa 399-740; RSK2 C-terminal kinase domain (CTD)
Residue:342
Sequence:
MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR
DPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASA
VLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP
CYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF
SLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHL
VKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
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  Blast E-value cutoff:
BDBM259805
n/a
NameBDBM259805
Synonyms:US9505766, CN-OMe (4)
TypeSmall organic molecule
Emp. Form.C21H21N5O3
Mol. Mass.391.4231
SMILESCOC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Structure
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