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TargetRibosomal protein S6 kinase alpha-3 [399-740]
LigandBDBM259839
Substrate/Competitorn/a
Meas. Tech.RSK2 Inhibition Assay
pH8±n/a
Temperature295.15±n/a K
IC50 3.8±n/a nM
Commentsextracted
Citation Taunton, Jr., JWMaglathlin, RSerafimova, ICohen, MSMiller, RPaavilainen, VMcFarland, JKrishnan, S Kinase inhibitors US Patent US9505766 Publication Date 11/29/2016
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase alpha-3 [399-740]
Name:Ribosomal protein S6 kinase alpha-3 [399-740]
Synonyms:ISPK1 | KS6A3_HUMAN | MAPKAPK1B | RPS6KA3 | RSK2 | Ribosomal S6 kinase 2 (RSK-2)
Type:Enzyme
Mol. Mass.:38435.14
Organism:Homo sapiens (Human)
Description:aa 399-740; RSK2 C-terminal kinase domain (CTD)
Residue:342
Sequence:
MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKR
DPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASA
VLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP
CYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF
SLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHL
VKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
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  Blast E-value cutoff:
BDBM259839
n/a
NameBDBM259839
Synonyms:US9505766, 43
TypeSmall organic molecule
Emp. Form.C24H28N6O3
Mol. Mass.448.5175
SMILESCc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)CO)n(CCCO)c2ncnc(N)c12
Structure
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