| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 [T175A] |
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| Ligand | BDBM259832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Nek2 Inhibition Assay |
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| pH | 7.6±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 440±n/a nM |
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| Comments | extracted |
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| Citation |  Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent US9505766 Publication Date 11/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase Nek2 [T175A] |
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| Name: | Serine/threonine-protein kinase Nek2 [T175A] |
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| Synonyms: | NEK2 | NEK2A | NEK2_HUMAN | NLK1 | Serine/threonine-protein kinase Nek2 (T175A) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51746.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human T175A NEK2 (referred to as "NEK2"). |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM259832 |
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| n/a |
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| Name | BDBM259832 |
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| Synonyms: | US9505766, 36 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N7O |
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| Mol. Mass. | 311.3418 |
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| SMILES | CNC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N |
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| Structure | 
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