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TargetHistamine H4 receptor
LigandBDBM294379
Substrate/Competitorn/a
Meas. Tech.HotSpot Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 73.0±n/a nM
Commentsextracted
Citation Ho, PSYoon, DOHan, SYLee, WIKim, JSPark, WSAhn, SOKim, HJ Substituted tricyclic heterocycles as histamine 4 receptor inhibitors US Patent US9586959 Publication Date 3/7/2017
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM294379
n/a
NameBDBM294379
Synonyms:US9586959, Compound 32
TypeSmall organic molecule
Emp. Form.C13H14ClN7
Mol. Mass.303.75
SMILESCc1nc2c3cc(Cl)cnc3nc(N3CCNCC3)n2n1
Structure
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