| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Replication protein A 70 kDa DNA-binding subunit |
|---|
| Ligand | BDBM61188 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Assay |
|---|
| IC50 | 20300±10700 nM |
|---|
| Citation |  Turchi, JJ; Shuck, S Materials and method for inhibiting replication protein A and uses thereof US Patent US9533969 Publication Date 1/3/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Replication protein A 70 kDa DNA-binding subunit |
|---|
| Name: | Replication protein A 70 kDa DNA-binding subunit |
|---|
| Synonyms: | REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68139.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27694 |
|---|
| Residue: | 616 |
|---|
| Sequence: | MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
|
|
|
|---|
| BDBM61188 |
|---|
| n/a |
|---|
| Name | BDBM61188 |
|---|
| Synonyms: | 4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid | 4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-pyrazol-4-yl]-3,4-dihydropyrazol-2-yl]-4-oxidanylidene-butanoic acid | 4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid | 4-keto-4-[5-[1-phenyl-3-(p-tolyl)pyrazol-4-yl]-3-(p-tolyl)-2-pyrazolin-1-yl]butyric acid | MLS000680473 | SMR000324613 | US9533969, TDRL-520 | cid_5055219 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H28N4O3 |
|---|
| Mol. Mass. | 492.5683 |
|---|
| SMILES | Cc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:8| |
|---|
| Structure | 
|
|---|
Search and Browse
