| Reaction Details |
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 | Report a problem with these data |
| Target | Replication protein A 70 kDa DNA-binding subunit |
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| Ligand | BDBM260648 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| IC50 | 71700±33900 nM |
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| Citation |  Turchi, JJ; Shuck, S Materials and method for inhibiting replication protein A and uses thereof US Patent US9533969 Publication Date 1/3/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Replication protein A 70 kDa DNA-binding subunit |
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| Name: | Replication protein A 70 kDa DNA-binding subunit |
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| Synonyms: | REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 68139.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27694 |
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| Residue: | 616 |
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| Sequence: | MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
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| BDBM260648 |
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| n/a |
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| Name | BDBM260648 |
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| Synonyms: | US9533969, TDRL-521 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28N4O4 |
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| Mol. Mass. | 508.5677 |
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| SMILES | COc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:9| |
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| Structure | 
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