| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Ligand | BDBM6746 |
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| Substrate/Competitor | Rb(21) |
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| Meas. Tech. | CDK Kinase Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 22±n/a nM |
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| Citation |  Zhu, G; Conner, SE; Zhou, X; Chan, HK; Shih, C; Engler, TA; Al-Awar, RS; Brooks, HB; Watkins, SA; Spencer, CD; Schultz, RM; Dempsey, JA; Considine, EL; Patel, BR; Ogg, CA; Vasudevan, V; Lytle, ML Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors. Bioorg Med Chem Lett14:3057-61 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 |
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| Synonyms: | CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1 | Cyclin-dependent kinase 4/cyclin D1 |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33717.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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| BDBM6746 |
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| Rb(21) |
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| Name: | Rb(21) |
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| Synonyms: | C-terminal retinoblastoma protein | RB1 | RB_HUMAN |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 17129.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Amino acids 769-921 of human retinoblastoma 1. |
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| Residue: | 153 |
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| Sequence: | LQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPR
SRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGS
KHLPGESKFQQKLAEMTSTRTRMQKQKMNDSMD
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