Reaction Details |
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Target | cAMP-dependent protein kinase catalytic subunit alpha |
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Ligand | BDBM6829 |
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Substrate/Competitor | Lysine-rich histone |
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Meas. Tech. | CDK Kinase Inhibition Assay |
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Temperature | 298.15±n/a K |
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IC50 | 3740±n/a nM |
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Comments | extracted |
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Citation | Engler, TA; Furness, K; Malhotra, S; Sanchez-Martinez, C; Shih, C; Xie, W; Zhu, G; Zhou, X; Conner, S; Faul, MM; Sullivan, KA; Kolis, SP; Brooks, HB; Patel, B; Schultz, RM; DeHahn, TB; Kirmani, K; Spencer, CD; Watkins, SA; Considine, EL; Dempsey, JA; Ogg, CA; Stamm, NB; Anderson, BD; Campbell, RM; Vasudevan, V; Lytle, ML Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles. Bioorg Med Chem Lett13:2261-7 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-dependent protein kinase catalytic subunit alpha |
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Name: | cAMP-dependent protein kinase catalytic subunit alpha |
Synonyms: | KAPCA_BOVIN | PKA C-alpha | PKC | PRKACA | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit |
Type: | Enzyme Complex |
Mol. Mass.: | 40627.77 |
Organism: | Bos taurus (bovine) |
Description: | The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction. |
Residue: | 351 |
Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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BDBM6829 |
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Lysine-rich histone |
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Name: | Lysine-rich histone |
Synonyms: | ING Peptide | Lys-rich histone | histone type IIIS |
Type: | Peptide |
Mol. Mass.: | 10508.21 |
Organism: | Bos taurus (bovine) |
Description: | Purified as a lysine rich fraction of histone H1 from calf thymus.
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Residue: | 105 |
Sequence: | SETAPAAPAAAPPAEKTPVKKKAAKKPAGARRKASGPPVSELITKAVAASKERSGVSLAA
LKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFK
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