| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [888-1187] |
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| Ligand | BDBM50332294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.5±n/a |
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| IC50 | 310±n/a nM |
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| Comments | extracted |
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| Citation |  Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent US10112907 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [888-1187] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [888-1187] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (aa 888-1187) | TYK2 | TYK2 (aa 888-1187) | TYK2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 34527.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597[888-1187] |
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| Residue: | 300 |
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| Sequence: | DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQE
IDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQI
CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW
YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTEL
LERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
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| BDBM50332294 |
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| n/a |
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| Name | BDBM50332294 |
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| Synonyms: | CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide | US10112907, Example 00018 | US10730860, TABLE 1.3 | US10766894, Compound TABLE 1.3 | US11203595, TABLE 1.3 | US11384069, Example T-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N6O3S |
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| Mol. Mass. | 524.678 |
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| SMILES | Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C |
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| Structure | 
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