| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [808-1132] |
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| Ligand | BDBM294916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.5±n/a |
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| IC50 | 30.0±n/a nM |
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| Comments | extracted |
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| Citation |  Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Substituted indazoles for treating tendon and/or ligament injuries US Patent US10112907 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [808-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [808-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132) |
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| Type: | Protein |
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| Mol. Mass.: | 39171.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[808-1132] |
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| Residue: | 335 |
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| Sequence: | FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGK
GNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVC
YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDL
ATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDV
WSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDE
IYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
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| BDBM294916 |
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| n/a |
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| Name | BDBM294916 |
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| Synonyms: | US10112907, Example 00027 | US10206907, Compound 176 | US10766894, Compound TABLE 1.12 | US10875847, Compound GLPG0634 | US11203595, TABLE 1.12 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N6O2 |
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| Mol. Mass. | 410.428 |
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| SMILES | O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1 |
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| Structure | 
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