| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM254326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding |
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| Ki | 2.80±n/a nM |
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| Citation |  Alcazar Vaca, MJ; Allison, BD; Andres Gil, JI; Chrovian, CC; Coate, HR; De Angelis, M; Deng, X; Dvorak, CA; Gelin, CF; Letavic, MA; Liang, JT; Mani, NS; Rech, JC; Savall, BM; Soyode-Johnson, A; Stenne, BM; Swanson, DM; Wall, JL P2X7 modulators and methods of use US Patent US10112937 Publication Date 10/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68403.50 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q64663 |
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| Residue: | 595 |
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| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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| BDBM254326 |
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| n/a |
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| Name | BDBM254326 |
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| Synonyms: | US10112937, Example 228 | US10150765, Example 228 | US10703749, Example 228 | US9464084, 228 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F5N7O |
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| Mol. Mass. | 425.3155 |
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| SMILES | C[C@H]1Cc2c(CN1C(=O)c1ccnc(c1F)C(F)(F)F)nnn2-c1ncc(F)cn1 |r| |
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| Structure | 
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