Reaction Details |
| Report a problem with these data |
Target | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
---|
Ligand | BDBM6768 |
---|
Substrate/Competitor | Autocamtide-2 |
---|
Meas. Tech. | Kinase Inhibition Assay |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 174±n/a nM |
---|
EC50 | 80±n/a nM |
---|
Comments | extracted |
---|
Citation | Zhu, G; Conner, SE; Zhou, X; Shih, C; Li, T; Anderson, BD; Brooks, HB; Campbell, RM; Considine, E; Dempsey, JA; Faul, MM; Ogg, C; Patel, B; Schultz, RM; Spencer, CD; Teicher, B; Watkins, SA Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem46:2027-30 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
---|
Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
Synonyms: | CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit |
Type: | Enzyme Mixture |
Mol. Mass.: | 54120.65 |
Organism: | Rattus norvegicus (rat) |
Description: | Consists of subunits of M.W. 50,000 and 58,000-60,000
in a 3:1 ratio. |
Residue: | 478 |
Sequence: | MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
|
|
|
BDBM6768 |
---|
Autocamtide-2 |
---|
Name: | Autocamtide-2 |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 3697.73 |
Organism: | n/a |
Description: | n/a |
Residue: | 36 |
Sequence: | Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu
|
|
|