Reaction Details |
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Target | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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Ligand | BDBM6870 |
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Substrate/Competitor | CaM Kinase II Peptide Substrate |
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Meas. Tech. | Kinase Inhibition Assay |
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IC50 | 10500±n/a nM |
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Citation | Lin, R; Connolly, PJ; Huang, S; Wetter, SK; Lu, Y; Murray, WV; Emanuel, SL; Gruninger, RH; Fuentes-Pesquera, AR; Rugg, CA; Middleton, SA; Jolliffe, LK 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem48:4208-11 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Calcium/calmodulin-dependent protein kinase type II subunit alpha |
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Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
Synonyms: | CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit |
Type: | Enzyme Mixture |
Mol. Mass.: | 54120.65 |
Organism: | Rattus norvegicus (rat) |
Description: | Consists of subunits of M.W. 50,000 and 58,000-60,000
in a 3:1 ratio. |
Residue: | 478 |
Sequence: | MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
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BDBM6870 |
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CaM Kinase II Peptide Substrate |
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Name: | CaM Kinase II Peptide Substrate |
Synonyms: | CaM Kinase II Peptide Substrate |
Type: | Peptide |
Mol. Mass.: | 2528.92 |
Organism: | n/a |
Description: | n/a |
Residue: | 22 |
Sequence: | (Biotin)KKALRRQETVDAL-Amide
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