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TargetTissue-type plasminogen activator
LigandBDBM298041
Substrate/Competitorn/a
Meas. Tech.Plasma-based Clot Lysis Assay
IC50 8.20±n/a nM
Citation Ellermann, MValot, GCancho Grande, YHaßfeld, JKinzel, TKöbberling, JBeyer, KRöhrig, SSperzel, MStampfuß, JMeyer, IKöllnberger, MBurkhardt, NSchlemmer, KStegmann, CSchuhmacher, JWerner, MHeiermann, JHengeveld, WJ Piperidinylpyrazolopyrimidinones and their use US Patent US10118930 Publication Date 11/6/2018
More Info.:Get all data from this article,  Assay Method
 
Tissue-type plasminogen activator
Name:Tissue-type plasminogen activator
Synonyms:Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator
Type:Enzyme
Mol. Mass.:62931.08
Organism:Homo sapiens (Human)
Description:n/a
Residue:562
Sequence:
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM298041
n/a
NameBDBM298041
Synonyms:3-(2-methyl-1,3-thiazol-5-yl)-7-(piperidin-4-yl)pyrazolo[1,5-c]pyrimidin-5(4H)-one hydrochloride | US10118930, Example 253
TypeSmall organic molecule
Emp. Form.C15H17N5OS
Mol. Mass.315.393
SMILESCc1ncc(s1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1
Structure
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