| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tissue-type plasminogen activator |
|---|
| Ligand | BDBM298114 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Plasma-based Clot Lysis Assay |
|---|
| IC50 | 12.0±n/a nM |
|---|
| Citation |  Ellermann, M; Valot, G; Cancho Grande, Y; Haßfeld, J; Kinzel, T; Köbberling, J; Beyer, K; Röhrig, S; Sperzel, M; Stampfuß, J; Meyer, I; Köllnberger, M; Burkhardt, N; Schlemmer, K; Stegmann, C; Schuhmacher, J; Werner, M; Heiermann, J; Hengeveld, WJ Piperidinylpyrazolopyrimidinones and their use US Patent US10118930 Publication Date 11/6/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tissue-type plasminogen activator |
|---|
| Name: | Tissue-type plasminogen activator |
|---|
| Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62931.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 562 |
|---|
| Sequence: | MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
DVPGVYTKVTNYLDWIRDNMRP
|
|
|
|---|
| BDBM298114 |
|---|
| n/a |
|---|
| Name | BDBM298114 |
|---|
| Synonyms: | 3-[(3,3-difluoroazetidin-1-yl)carbonyl]-7-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidin-5 (4H)-one hydrochloride | US10118930, Example 326 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17F2N5O2 |
|---|
| Mol. Mass. | 337.3246 |
|---|
| SMILES | FC1(F)CN(C1)C(=O)c1cnn2c(cc(=O)[nH]c12)C1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
