Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Tissue-type plasminogen activator | ||
Ligand | BDBM298180 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Plasma-based Clot Lysis Assay | ||
IC50 | 15.0±n/a nM | ||
Citation | Ellermann, M; Valot, G; Cancho Grande, Y; Haßfeld, J; Kinzel, T; Köbberling, J; Beyer, K; Röhrig, S; Sperzel, M; Stampfuß, J; Meyer, I; Köllnberger, M; Burkhardt, N; Schlemmer, K; Stegmann, C; Schuhmacher, J; Werner, M; Heiermann, J; Hengeveld, WJ Piperidinylpyrazolopyrimidinones and their use US Patent US10118930 Publication Date 11/6/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tissue-type plasminogen activator | |||
Name: | Tissue-type plasminogen activator | ||
Synonyms: | Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator | ||
Type: | Enzyme | ||
Mol. Mass.: | 62931.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 562 | ||
Sequence: |
| ||
BDBM298180 | |||
n/a | |||
Name | BDBM298180 | ||
Synonyms: | 3-[5-(2-Methylprop-1-en-1-yl)-1,2,4-oxadiazol-3-yl]-7-(piperidin-4-yl)pyrazolo[1,5-a]pyrimidin-5 (4H)-one hydrochloride | US10118930, Example 383 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H20N6O2 | ||
Mol. Mass. | 340.3797 | ||
SMILES | CC(C)=Cc1nc(no1)-c1cnn2c(cc(=O)[nH]c12)C1CCNCC1 |(5.75,5.52,;4.26,5.12,;3.17,6.21,;3.86,3.64,;2.37,3.24,;1.9,1.77,;.36,1.77,;-.12,3.24,;1.13,4.14,;-.73,.68,;-2.26,.84,;-2.89,-.56,;-1.75,-1.59,;-1.75,-3.13,;-.41,-3.9,;.92,-3.13,;2.26,-3.9,;.92,-1.59,;-.41,-.82,;-3.08,-3.9,;-4.41,-3.13,;-5.75,-3.9,;-5.75,-5.44,;-4.41,-6.21,;-3.08,-5.44,)| | ||
Structure |