| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 2 |
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| Ligand | BDBM161439 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FGFR2 Kinase Activity |
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| IC50 | 1.000±n/a nM |
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| Citation |  Sootome, H Therapeutic agent for FGFR inhibitor-resistant cancer US Patent US10124003 Publication Date 11/13/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 2 |
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| Name: | Fibroblast growth factor receptor 2 |
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| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 92015.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21802 |
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| Residue: | 821 |
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| Sequence: | MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
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| BDBM161439 |
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| n/a |
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| Name | BDBM161439 |
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| Synonyms: | US10124003, Ex. Compound 52 | US10894048, Ex Comp 52 | US9108973, 52 | US9108973, 52/56 | US9108973, 56 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N6O3 |
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| Mol. Mass. | 460.5282 |
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| SMILES | COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12 |
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| Structure | 
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