Ki Summary

Reaction Details

Report a problem with these data

Target

Isoform C of Bromodomain-containing protein 4 (Short)

Ligand

BDBM298346

Substrate/Competitor

n/a

1500±n/a nM

Citation

Landau, SB; Kagey, M Bromodomain inhibitors US Patent US10124009 Publication Date 11/13/2018

More Info.:

Get all data from this article, Assay Method

Isoform C of Bromodomain-containing protein 4 (Short)

Name:

Isoform C of Bromodomain-containing protein 4 (Short)

Synonyms:

BET bromodomain 4 (BRD4) | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (Short) | HUNK1

Type:

n/a

Mol. Mass.:

80477.46

Organism:

Homo sapiens (Human)

Description:

O60885-2

Residue:

722

Sequence:

MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETG
PA

BDBM298346

n/a

Name

BDBM298346

Synonyms:

US10124009, Compound 1

Type

Small organic molecule

Emp. Form.

C25H27ClN4O3S

Mol. Mass.

499.025

SMILES

Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)OC1CCC(O)CC1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,wD:9.10,c:8,(-6.28,-3.66,;-5.38,-2.42,;-5.85,-.95,;-4.61,-.05,;-3.36,-.95,;-3.84,-2.42,;-2.93,-3.66,;-1.88,-.54,;-1.27,.87,;-2,2.23,;-1.23,3.56,;.31,3.56,;1.08,4.9,;1.08,2.23,;2.62,2.23,;3.39,.9,;4.93,.9,;5.7,2.23,;7.24,2.23,;4.93,3.56,;3.39,3.56,;-3.52,2.51,;-4.16,3.9,;-5.69,3.72,;-5.99,2.21,;-7.39,1.56,;-4.64,1.46,;-.79,-1.63,;-1.18,-3.12,;-.1,-4.21,;1.39,-3.81,;2.48,-4.9,;1.79,-2.32,;.7,-1.23,)|

Structure