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TargetBromodomain-containing protein 4 Isoform C
LigandBDBM298348
Substrate/Competitorn/a
Kd 1200±n/a nM
Citation Landau SBKagey M Bromodomain inhibitors US Patent  US10124009 Publication Date 11/13/2018
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 Isoform C
Name:BET bromodomain 4 (BRD4)
Synonyms:n/a
Type:n/a
Mol. Mass.:80477.46
Organism:Homo sapiens (Human)
Description:O60885-2
Residue:722
Sequence:
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETG
PA
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  Blast E-value cutoff:
BDBM298348
n/a
NameBDBM298348
Synonyms:US10124009, Compound 3
TypeSmall organic molecule
Emp. Form.C21H21ClN4O3S
Mol. Mass.444.934
SMILESCc1sc-2c(c1C)C(=N[C@@H](CC(=O)OCCO)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8|
Structure
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