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TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
LigandBDBM7264
Substrate/CompetitorHistone H1
Meas. Tech.Kinase Inhibition Assay
pH7.2±n/a
Temperature303.15±n/a K
IC50 24±n/a nM
Citation Leost, M; Schultz, C; Link, A; Wu, YZ; Biernat, J; Mandelkow, EM; Bibb, JA; Snyder, GL; Greengard, P; Zaharevitz, DW; Gussio, R; Senderowicz, AM; Sausville, EA; Kunick, C; Meijer, L Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem267:5983-94 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
Name:Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
Synonyms:CDK1/Cyclin B | Cyclin-Dependent Kinase 1 (CDK1) | p34cdc2/Cyclin B
Type:Protein Complex
Mol. Mass.:n/a
Description:p34cdc2/cyclin B was purified from M-phase starfish oocytes by affinity chromatography.
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 1
Synonyms:CDK1_ORYLA | Cell division control protein 2 (cdc2) | P34 protein kinase | cdc2 | cdk1
Type:Enzyme Subunit
Mol. Mass.:34693.35
Organism:Marthasterias glacialis (starfish)
Description:Q9DGD3 {empty hard to find)
Residue:303
Sequence:
MEDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKH
PNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH
RRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPR
YSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNT
FPKWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLDKSTLPAACI
NGV
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  Blast E-value cutoff:
Component 2
Name:G2/mitotic-specific cyclin-B
Synonyms:CCNB_MARGL | Cyclin B | G2/mitotic-specific cyclin-B1
Type:Enzyme Subunit
Mol. Mass.:43790.28
Organism:Marthasterias glacialis (starfish)
Description:n/a
Residue:388
Sequence:
MLNGENVDSRIMGKVATRASSKGVKSTLGTRGALENISNVARNNLQAGAKKELVKAKRGM
TKSKATSSLQSVMGLNVEPMEKAKPQSPEPMDMSEINSALEAFSQNLLEGVEDIDKNDFD
NPQLCSEFVNDIYQYMRKLEREFKVRTDYMTIQEITERMRSILIDWLVQVHLRFHLLQET
LFLTIQILDRYLEVQPVSKNKLQLVGVTSMLIAAKYEEMYPPEIGDFVYITDNAYTKAQI
RSMECNILRRLDFSLGKPLCIHFLRRNSKAGGVDGQKHTMAKYLMELTLPEYAFVPYDPS
EIAAAALCLSSKILEPDMEWGTTLVHYSAYSEDHLMPIVQKMALVLKNAPTAKFQAVRKK
YSSAKFMNVSTISALTSSTVMDLADQMC
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  Blast E-value cutoff:
BDBM7264
Histone H1
Name:Histone H1
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:n/a
Residue:3
Sequence:
n/a