Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetE3 ubiquitin-protein ligase Mdm2 [1-188]
LigandBDBM50448963
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay)
IC50 0.100±n/a nM
Citation Bartberger, MDGonzalez Buenrostro, ABeck, HPChen, XConnors, RVDeignan, JDuquette, JAEksterowicz, JFisher, BFox, BMFu, JFu, ZGonzalez Lopez De Turiso, FGribble, Jr., MWGustin, DJHeath, JAHuang, XJiao, XJohnson, MGKayser, FKopecky, DJLai, SLi, YLi, ZLiu, JLow, JDLucas, BSMa, ZMcGee, LRMcIntosh, JMcMinn, DLMedina, JCMihalic, JTOlson, SHRew, YRoveto, PMSun, DWang, XWang, YYan, XYu, MZhu, J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent US9593129 Publication Date 3/14/2017
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2 [1-188]
Name:E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:Q00987[1-188]
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50448963
n/a
NameBDBM50448963
Synonyms:CHEMBL3125537 | US9296736, 351 | US9593129, Example 351
TypeSmall organic molecule
Emp. Form.C29H35Cl2NO5S
Mol. Mass.580.563
SMILESCC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: