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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50053040
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay)
IC50 0.100±n/a nM
Citation Bartberger MDGonzalez Buenrostro ABeck HPChen XConnors RVDeignan JDuquette JAEksterowicz JFisher BFox BMFu JFu ZGonzalez Lopez De Turiso FGribble, Jr. MWGustin DJHeath JAHuang XJiao XJohnson MGKayser FKopecky DJLai SLi YLi ZLiu JLow JDLucas BSMa ZMcGee LRMcIntosh JMcMinn DLMedina JCMihalic JTOlson SHRew YRoveto PMSun DWang XWang YYan XYu MZhu J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent  US9593129 Publication Date 3/14/2017
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:E3 ubiquitin-protein ligase Mdm2 (aa 1-188)
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50053040
n/a
NameBDBM50053040
Synonyms:CHEMBL3318760 | US9296736, 378 | US9593129, Example 378
TypeSmall organic molecule
Emp. Form.C28H34Cl2N2O5S
Mol. Mass.581.551
SMILESCC(C)NS(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
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