Reaction Details |
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Target | Cyclin homolog/dependent kinase 6 |
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Ligand | BDBM7459 |
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Substrate/Competitor | Histone H1 |
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Meas. Tech. | Kinase Inhibition Assay |
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pH | 7±n/a |
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Temperature | 303.15±n/a K |
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IC50 | >300000±n/a nM |
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Citation | Lu, H; Chang, DJ; Baratte, B; Meijer, L; Schulze-Gahmen, U Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem48:737-43 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cyclin homolog/dependent kinase 6 |
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Name: | Cyclin homolog/dependent kinase 6 |
Synonyms: | CDK6/Vcyclin | Cyclin-Dependent Kinase 6 (CDK6) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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Component 2 |
Name: | Cyclin homolog |
Synonyms: | 72 | CGH2_SHV21 | ECLF2 | Vcyclin | viral cyclin |
Type: | Enzyme Subunit |
Mol. Mass.: | 28634.62 |
Organism: | Saimiriine herpesvirus 2 |
Description: | Sf9 insect cells were infected with recombinant baculovirus containing the His-tagged Vcyclin gene. The protein was purified over a Talon column (BD Biosciences Clontech, Palo Alto, CA) followed by a Source Q ion-exchange column (Amersham Bioscience, Piscataway, NJ). The N-terminal His tag was removed from Vcyclin using recombinant tobacco etch virus protease. |
Residue: | 254 |
Sequence: | MADSPNRLNRAKIDSTTMKDPRVLNNLKLRELLLPKFTSLWEIQTEVTVDNRTILLTWMH
LLCESFELDKSVFPLSVSILDRYLCKKQGTKKTLQKIGAACVLIGSKIRTVKPMTVSKLT
YLSCDCFTNLELINQEKDILEALKWDTEAVLATDFLIPLCNALKIPEDLWPQLYEAASTT
ICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKD
QVSEAFSLYDLEIL
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BDBM7459 |
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Histone H1 |
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Name: | Histone H1 |
Synonyms: | n/a |
Type: | Other Protein Type |
Mol. Mass.: | 358.43 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 3 |
Sequence: | |