| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Wnt-3a |
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| Ligand | BDBM300610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HCT116 FOPFlash |
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| IC50 | >50000±n/a nM |
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| Comments | 0.000 12/22/2021 |
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| Citation |  Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent US10130633 Publication Date 11/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Wnt-3a |
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| Name: | Protein Wnt-3a |
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| Synonyms: | WNT3A | WNT3A_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39379.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469237 |
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| Residue: | 352 |
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| Sequence: | MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
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| BDBM300610 |
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| n/a |
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| Name | BDBM300610 |
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| Synonyms: | N-[6-(3,5- difluorophenyl)pyridin-3-yl]-3- ({(2R*)-2-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5- yl]propanoyl}amino)-4- (trifluoromethoxy)benzamide | US10130633, Example 180 | US10130633, Example 181 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23F5N4O4 |
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| Mol. Mass. | 562.4879 |
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| SMILES | CC(N1C[C@@H]2C[C@H]1CO2)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1cc(F)cc(F)c1 |r| |
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| Structure | 
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