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TargetEndothelin-1
LigandBDBM172585
Substrate/Competitorn/a
Meas. Tech.ET-1 Assay
EC50<50000±n/a nM
Citation PubChem PCBuckman BONicholas JBRamphal JYEmayan KSeiwert SD Anti-fibrotic pyridinones US Patent  US9675593 Publication Date 6/13/2017
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1
Name:Endothelin-1
Synonyms:PPET1 | Preproendothelin-1
Type:Protein
Mol. Mass.:24444.51
Organism:Homo sapiens (Human)
Description:P05305
Residue:212
Sequence:
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM172585
n/a
NameBDBM172585
Synonyms:US9675593, 651
TypeSmall organic molecule
Emp. Form.C21H19F3N4O3
Mol. Mass.432.3958
SMILESCOCCn1ccc2c(cn(-c3ccc(OC(F)(F)F)cc3)c(=O)c12)-c1cnn(C)c1
Structure
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