Ki Summary

Reaction Details

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Target

Endothelin-1

Ligand

BDBM172590

Substrate/Competitor

n/a

Meas. Tech.

ET-1 Assay

EC50

<50000±n/a nM

Citation

PubChem, PC; Buckman, BO; Nicholas, JB; Ramphal, JY; Emayan, K; Seiwert, SD Anti-fibrotic pyridinones US Patent US9675593 Publication Date 6/13/2017

More Info.:

Get all data from this article, Assay Method

Endothelin-1

Name:

Endothelin-1

Synonyms:

EDN1 | EDN1_HUMAN | PPET1 | Preproendothelin-1

Type:

Protein

Mol. Mass.:

24444.51

Organism:

Homo sapiens (Human)

Description:

P05305

Residue:

212

Sequence:

MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW

BDBM172590

n/a

Name

BDBM172590

Synonyms:

US9675593, 667

Type

Small organic molecule

Emp. Form.

C19H15FO3

Mol. Mass.

310.319

SMILES

CCOc1ccc(-c2c(-c3ccc(F)cc3)c(=O)c2=O)c(C)c1 |(4.52,-5.84,;3.45,-4.74,;3.86,-3.25,;2.79,-2.15,;1.26,-2.46,;.17,-1.37,;.57,.12,;-.52,1.21,;-2.06,1.21,;-3.15,.12,;-4.63,.52,;-5.72,-.57,;-5.33,-2.06,;-6.41,-3.15,;-3.84,-2.46,;-2.75,-1.37,;-2.06,2.75,;-3.15,3.84,;-.52,2.75,;.57,3.84,;2.06,.52,;2.46,2.01,;3.15,-.57,)|

Structure