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TargetPotassium channel subfamily K member 3
LigandBDBM179629
Substrate/Competitorn/a
Meas. Tech.Activity Assay
IC50 99.5±n/a nM
Citation Bialy, LLorenz, KWirth, KSteinmeyer, KHessler, GPernerstorfer, JBrendel, J Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them US Patent US9598410 Publication Date 3/21/2017
More Info.:Get all data from this article,  Assay Method
 
Potassium channel subfamily K member 3
Name:Potassium channel subfamily K member 3
Synonyms:Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:Protein
Mol. Mass.:43534.71
Organism:Homo sapiens (Human)
Description:O14649
Residue:394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
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BDBM179629
n/a
NameBDBM179629
Synonyms:US9127001, 6g | US9598410, Compound 6g
TypeSmall organic molecule
Emp. Form.C21H18F4N4O
Mol. Mass.418.3874
SMILESCC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1)-c1cccc(n1)C(F)(F)F
Structure
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