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TargetPlasmepsin I
LigandBDBM7979
Substrate/CompetitorPeptide Substrate
Meas. Tech.Enzyme Inhibition Measurements
Ki 3.9±n/a nM
Citation Johansson, POChen, YBelfrage, AKBlackman, MJKvarnstrom, IJansson, KVrang, LHamelink, EHallberg, ARosenquist, ASamuelsson, B Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. J Med Chem47:3353-66 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Plasmepsin I
Name:Plasmepsin I
Synonyms:PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor
Type:Enzyme
Mol. Mass.:51463.30
Organism:Plasmodium falciparum
Description:n/a
Residue:452
Sequence:
MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM7979
Peptide Substrate
Name:Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3501.67
Organism:n/a
Description:n/a
Residue:31
Sequence:
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS