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Assay Method Information |
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| | Electrophysiology Assay |
| Description: | Compounds were tested using a PatchXpress (Model 7000A, Molecular Devices, Union City Calif.) on CHO cells over-expressing h KCa3.1 at ChanTest Corporation, 14656 Neo Parkway, Cleveland, Ohio.The compounds I of the present invention exhibit IC50 values in the patch clamp assay of 10 nM to 10 μM, preferably 10 nM to 1 μM for patch clamp. |
| Affinity data for this assay | |
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