Search and Browse
Download
Enter Data
|
Assay Method Information |
|
| | In vitro MKP-1 Phosphatase Dose Response SAR Support Assay |
| Description: | The MKP-1 dose response assay SAR support Assay - has been developed to test the activity of a series Analog compounds synthesized by the PMLSC Chemistry Core based on MKP-1 inhibitors identified in the MH-76391 In vitro HTS assay for MKP-1 inhibitors AID 374 and subsequently confirmed in the MKP-1 HTS dose response confirmation assay AID 551. The MKP-1 Phosphatase dose response SAR support assay has been Developed and Run at the University of Pittsburgh Molecular Screening Center (PMLSC) part of the Molecular Library Screening Center Network (MLSCN). XO1 submission MH-76391 In vitro HTS assay for MKP-1, Assay Provider Dr. John S. Lazo, Department of Pharmacology at the University of Pittsburgh. The 107 protein tyrosine phosphatases (PTPs) found in the human genome are defined by the active site sequence C(X)5R(S/T), with X being any amino acid, and they are critical regulators of mammalian cell proliferation, differentiation, and apoptosis. PTPs can be divided into at least four s |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||