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Assay Method Information

Assay Name:  Dose-response biochemical assay of inhibitors of Rho kinase 2 (Rock2)
Description:  Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Scripps Florida Network: Molecular Library Screening Center Network (MLSCN) Proposal Number: None External Assay ID: Rock2_INH_ LUMI_1536_ IC50 Name: Dose-response biochemical assay of inhibitors of Rho kinase 2 (Rock2) Description: Rho-Kinase is a serine/threonine kinase involved in the regulation of smooth muscle contraction and cytoskeletal reorganization of nonmuscle cells (1). Its inhibition is known to promote the smooth muscle relaxation. Thus, small-molecule inhibitors of Rho-Kinase may be effective probes for treatment of cerebral vasospasm (2) and potentially effective for treatment of angina (3), hypertension (4), arteriosclerosis (5), and erectile dysfunction (6). References: [1] Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV. Kinetic mechanism for human Rho-Kinase II (ROCK-II).Biochemistry. 2002 J
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Last update November 1, 2007
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