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Assay Method Information

Assay Name:  West Nile Virus NS2bNS3 Proteinase Inhibitor Dose Response Confirmation.
Description:  The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH077601, and was developed and screened at the University of Pittsburgh Molecular Library Screening Center part of the Molecular Library Screening Center Network (MLSCN). The 10-point IC50 dose response confirmation assay was developed and run at the PMLSC to confirm the activity of WNV NS2bNS3 Proteinase inhibitors identified in the primary HTS, AID 577. Extracted from the XO1-MH077601 Proposal submitted by Dr. Alex Strongin, Burnham Institute: West Nile virus, a member of the Flaviviridae family, was first isolated in 1937 in the West Nile district of Uganda. West Nile virus is transmitted to animals including humans, through mosquito bites. Mosquitoes become infected when they feed on infected birds. In 2003, West Nile virus was detected in as many as 46 of the United States. The virus infected as many as 10,000 people and was the cause
Affinity data for this assay
 

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Last update November 1, 2007
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