Search and Browse
Download
Enter Data
|
Assay Method Information |
|
| | MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment: Cdc25B Dose Response Selectivity Assay |
| Description: | The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PTP selectivity of actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibitors. The MKP-1 HTS assay was screened by the PMLSC against the year 1 full diversity NIH compound library (65,239 compounds) and the data were uploaded to the PubChem database AID 374. The PMLSC confirmed the actives from the MKP-1 screen in dose response assays and uploaded the data to the PubChem database AID 551. The 107 protein tyrosine phosphatases (PTPs) found in the human genome are defined by the active site sequence C(X)5R(S/T), with X being any amino acid, and they are critical regulators of mammalian cell proliferation, differentiation, and apoptosis. PTPs can be divided into at least four subfamilies based on their tertiary structure: Classical phosphotyrosine specific PTPs, dual specificity phosphatases (DSPase), Cdc25 phosphatases and |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||