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| | Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation |
| Description: | NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, University of Illinois at Urbana-Champaign MLSCN Grant: 1 X01MH78953-01 Title: HTS for Estrogen Receptor-alpha Coactivator Binding inhibitors Assay Overview Estrogens, which are responsible for the growth of many breast cancers, act through the estrogen receptors, ER-alpha and ER-beta, which are ligand-modulated transcription factors and members of the nuclear receptor gene superfamily. ER-alpha and ER-beta are well validated protein targets for various aspects of women's health and breast cancer prevention and treatment. As an essential step in their action as regulators of gene transcription, the ERs recruit various coregulator proteins, both coactivators and corepressors, to the DNA-bound (or protein tethered) ER. These coregulators have various activities: alteration of chromatin architecture, regulation of nucleosome core |
| Affinity data for this assay | |
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