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Assay Method Information

Assay Name:  High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Confirmatory Screen
Description:  Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening Centers Network (MLSCN) Submitted by Dr. Cynthia Stauffacher (Purdue University) Award: 1-R03-MH082373-01 A number of common human pathogens, including Enterococcus faecalis, Streptococcus pneumoniae, and Staphylococcus aureus, are becoming progressively more resistant to antibiotics and pose a serious public health threat, especially to post-surgical and trauma patients. Therefore, the discovery of drugs targeting novel pathways in these pathogens has become increasingly important. The synthesis of isoprenoids, which in these gram-positive pathogenic bacteria (Hedl, 2002) occurs exclusively via the mevalonate pathway, is essential for their survival. The central mevalonate pathway enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR; EC 1.1.1.34), reduces HMG-CoA to mevalonate using NADPH (Hedl, 2004). Bacterial HMG-CoA redu
Affinity data for this assay
 

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Last update November 1, 2007
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