Search and Browse
Download
Enter Data
|
Assay Method Information |
|
| | Estrogen Receptor-beta Coactivator Binding Inhibitors ELISA Secondary Assay |
| Description: | NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, University of Illinois Urbana-Champaign MLSCN Grant: 1 X01MH78953-01 Assay Overview Estrogens, which are responsible for the growth of many breast cancers, act through the estrogen receptors, ER-alpha and ER-beta, which are ligand-modulated transcription factors and members of the nuclear receptor gene superfamily. ER-alpha and ER-beta are well validated protein targets for various aspects of women's health and breast cancer prevention and treatment. As an essential step in their action as regulators of gene transcription, the ERs recruit various coregulator proteins, both coactivators and corepressors, to the DNA-bound (or protein tethered) ER. These coregulators have various activities: alteration of chromatin architecture, regulation of nucleosome core histone modifications (acetylation, methylation, phosphorylation), and ac |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |
|
Home |
| |
Search |
| |
Deposit |
| |
SiteMap |
| |
About us |
| |
Email us |
| |
Info |
|
©2000 BindingDB. All rights reserved. |
|||||||||||||