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| | Dose-Response of Allosteric Antagonists for the VLA-4 Integrin |
| Description: | Assay Support: 1 X01 MH077638-01 MLSCN Assay for Allosteric Ligands for the VLA-4 Integrin PI: SKLAR, LARRY A University of New Mexico Assay Overview: This is a high throughput flow cytometry cell-based assay to measure dose response of small molecules# allosteric inhibition of integrin alpha-4-beta-1 heterodimer very late antigen (VLA-4). Inhibition of VLA-4 activation affects the affinity and conformation of integrins. Affinity states have been directly evaluated by a peptide ligand derived from the LDV sequence of a native ligand binding region for VLA-4. These dose response assessments report IC50. |
| Affinity data for this assay | |
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