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| | Fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 5 (PP5) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Richard Honkanen, University of South Alabama Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 MH085702-01A1 Grant Proposal PI: Richard Honkanen, University of South Alabama External Assay ID: PP5_INH_FLINT_1536_3X%IC50 DRUN Name: Fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 5 (PP5). Description: Numerous essential biological processes, including transcription and mitosis require the kinase-mediated phosphorylation of target proteins at serine and threonine residues, which leads to activation, inactivation, degradation, or subcellular relocalization of the specific target. The actions of these kinases are opposed by the serine/threonine phosphoprotein phosphatases (PPPs). Although much is known about serine/ |
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