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Assay Method Information

Assay Name:  SAR Analysis of Selective Antagonists of GPR55 using an Image-Based Assay
Description:  Data Source: Sanford-Burnham Center for Chemical Genomics(SSBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA) Network: NIH Molecular Libraries Probe Production Centers Network (MLPCN) Grant Number: 1X01 MH085708-01 Assay Provider: Dr. Lawrence Barak, Duke University, Durham, NC Addictive behavior stems from abnormal signaling activities in the brain. Thus identification of compounds blocking this modified signaling activity may lead to treatments for addictive behavior. GPR35, a to-date uncharacterized orphan G-Protein Coupled Receptor, is thought to play a role in addiction and has homology to other known receptors of abuse. This high-content imaging assay was used as a counter screen for hits originally identified in a high-content screen for antagonists of the GPR35 receptor "Image-based HTS for Selective Antagonists of GPR35" (AID 2058) and to study the structure-activity relationship on analogs of the confirmed hits. Compounds are ei
Affinity data for this assay
 

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Last update November 1, 2007
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