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Assay Method Information

Assay Name:  Luminescence Cell-Based Secondary Assay to Identify Inhibitors of Hsp90
Description:  Keywords: Candida albicans, drug resistance, Fluconazole, Hsp90, stress response Assay Overview: Method for determining if compound acts as Hsp90 inhibitor. Saccharomyces strain expressing B-galactosidase driven by glucocorticoid response element is exposed to compounds. Loss of signal indicates interference with hsp90 function. Expected Outcome: Reduction of signal indicates hsp90 inhibition by compound.
Affinity data for this assay
 

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Last update November 1, 2007
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