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Assay Method Information

Assay Name:  Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 (Round 1)
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Vincent Yang, Emory University Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1-R03-DA026215-01 Grant Proposal PI: Vincent Yang External Assay ID: KLF5_INH_LUMI_1536_3X1C50 MDRUN SAR_Round_1 Name: Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 (Round 1). Description: Transcription factors are essential regulators of transcription that bind DNA to control both the rate and frequency of gene expression (1). Many diseases of cell homeostasis are associated with aberrant transcription factor activity (2). Colon cancer, in particular, is a disease of uncontrolled proliferation of the epithelial cells that line the intestinal crypts. Kruppel-like factor 5 (KLF5)
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Last update November 1, 2007
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