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| | Counterscreen for NR2E3 inverse agonists |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Konstantin Petrukhin, Columbia University Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R21 NS061718-01 Fast Track Grant Proposal PI: Konstantin Petrukhin, Columbia University External Assay ID: PPARG-NCOR2_IAG_HTRF_1536_3XIC50 DCSRUN Name: Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2). Description: Nuclear receptors are small molecule- and hormone-regulated transcription factors with discrete DNA-binding and ligand-binding domains, and are essential during development and for maintenance of proper cell function in adults. Small pharmacological compounds that bind to the cle |
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