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Assay Method Information

Assay Name:  Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
Description:  Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Gerald R. Smith, Fred Hutchinson Cancer Research Center Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: GM031693 Grant Proposal PI: Gerald R. Smith External Assay ID: RECBCD_INH_ABS_1536_3XIC50 DCSRUN + phage Name: Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD. Description: Helicobacter pylori infects approximately half of the world's population and is responsible for inducing chronic gastric inflammation that can progress to gastric cancer (1). At the cellular level, Helicobacter pylori infection of the human stomach is associated with inflammation that elicits DNA damage in both bacterial and host cells (2). This DNA damage must be repaired in order for the bacteria to persist. Th
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Last update November 1, 2007
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