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Assay Method Information

Assay Name:  Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
Description:  Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA) Network: NIH Molecular Libraries Probe Production Centers Network (MLPCN) Grant Number: 1 R03 DA027714-01A1 Assay Provider: Dr. Carla Koehler, University of California, Los Angeles, CA (UCLA) Defects in mitochondrial assembly impact a wide range of diseases from degenerative muscle and neural diseases to cancer (Wallace, 2005). The mitochondrion is not only important for the production of energy but plays an important role in other aspects such as intermediary metabolism and signaling. The mitochondrion contains an inner membrane and outer membrane that separate the matrix from the intermembrane space. Proteins destined for the mitochondrion are imported via the Translocase of the Outer Membrane (TOM) and the Translocases of the Inner Membrane (TIM23 for proteins destined for the matrix and TIM22 for proteins destined for the inner me
Affinity data for this assay
 

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Last update November 1, 2007
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